Research

Shockwave Treatment of Erectile Dysfunction

-Ilan Gruenwald, Boaz Appel, Noam D. Kitrey and Yoram Vadri

“Low-intensity extracorporeal wave therapy is a REVOLUTIONARY treatment of ED, and probably possesses unprecedented qualities that can REHABILITATE erectile tissue.”

Penile Low Intensity Shock Wave Treatment is Able to Shift PDE5i Nonresponders to Responders: A Double-Blind Study

-Noam D. Kitrey, Ilan Gruenwald, Boaz Appel, Arik Schechter, Omar Massarwa and Yoram Vardi

“Low intensity wave treatment is effective even in patients with severe erectile dysfunction who are PDE5i (Viagra, Cialis, etc.) nonresponders.”

Impact of Aging and Comorbidity on the Efficacy of Low-Intensity Shock Wave Therapy for Erectile Dysfunction

-S. Hisasue, T. China, A. Horiuchi, M. Kimura, K. Saito, S. Isotani, H. Ide, S. Muto, R. Yamaguchi, and S. Horie

“The sexual health inventory for men and erection hardness score (with and without PDE5i drugs) WERE SIGNIFICANTLY INCREASED AT EACH TIME POINT.”

“THE MEAN PENILE CIRCUMFERENTIAL CHANGE WAS ALSO INCREASED FROM 13.1 to 20.2 mm after low-intensity wave therapy.”

Extracorporeal Shockwave Therapy in the Treatment of Erectile Dysfunction: A Prospective, Randomized, Double-Blinded, Placebo Controlled Study

-Chi Hang Lee, Eddie SY Chan, Simon See-Ming Hou and Chi-Fai Ng

“This could be one of the few non-pharmacological ED treatment modalities with REHABILITATIVE features.”

Twelve-Month Efficacy and Safety of Low-Intensity Shockwave Therapy for Erectile Dysfunction in Patients Who Do Not Respond to Phosphodiesterase Type 5 Inhibitors

-Amado Bechara, Adolfo Casabe, Walter De Bonis, and Pablo Gomez Ciciclia

“Low-intensity wave therapy with ED unresponsive to PDE5i (Viagra, Cialis, etc.) treatment was effective and safe in 60% of patients.  The efficacy response was maintained for 12 months.”

Low-Intensity Extracorporeal Shock Wave Treatment Improves Erectile Function: A Systematic Review and Meta-Analysis

-Zhihua Lu, Guiting Lin, Amanda Reed-Maldonado, Chunxi Wang, Yung-Chin Lee, and Tom F. Lue

“The mechanism of low-intensity wave therapy is to improve or even IMPROVE THE PATHOLOGICAL DAMAGE OF TISSUE THAT CAUSES ED.  From our review, it is clear that low-intensity wave therapy may have the potential to be the first-choice noninvasive treatment for patients with ED.”

Shock Wave Therapy Induces Neovascularization at the Tendon-Bone Junction, A Study in Rabbits

-C. Wang, F. Wang, K. Yang, L. Weng, C. Hsu, C. Huang, L. Yang

“The results show that wave therapy produced a SIGNIFICANTLY HIGHER NUMBER OF NEO-VESSELS and angiogenesis-related markers including vessel endothelial growth factor (VEGF) and ENDOTHELIAL CELL PROLIFERATION determined by proliferating cells nuclear antigen (PCNA).

Extracorporeal Cardiac Shock Wave Therapy Markedly Ameliorates Ischemia-Induced Myocardial Dysfunction in Pigs in Vivo

– T. Nishida, H. Shimokawa, K. Oi, H. Tatewaki, T. Uwatoku, K. Abe, Y. Matsumoto et al.

“Extracorporeal wave therapy to the ischemic dysfunction region was performed which induced A COMPLETE RECOVERY OF LEFT VENTRICULAR EJECTION FRACTION, WALL THICKENING FRACTION, AND REGIONAL MYOCARDIAL BLOOD FLOW.”

Extracorporeal Cardiac Shock Wave Therapy Ameliorates Myocardial Ischemia in Patients with Severe Coronary Artery Disease

-Y. Fukumoto, A. Ito, T. Uwatoku, T. Matoba, T. Kishi, H. Tanaka, A. Takeshita, et al.

“These results indicate that our extracorporeal cardiac wave therapy is an EFFECTIVE AND NON-INVASIVE TREATMENT FOR END-STAGE CORONARY ARTERY DISEASE.”

Safety and Efficacy of Low Intensity Shockwave (LISW) Treatment in Patients With Erectile Dysfunction

-A. Ruffo, M. Capece, D. Prezioso, G. Romeo, E. Illiano, L. Romis, G. Di Lauro, and F. Iacono

“Unfortunately, oral therapies are limited for being used before the sexual act and do not modify the physiologic mechanism of penile erection.   The primary goal in the management of patients with ED would be to determine its etiology and cure when possible, and not just treatment of symptoms.  One of the new therapeutic strategies is the use of low intensity extracorporeal therapy.”

“Low-intensity wave therapy has a well-documented positive CLINICAL AND PHYSIOLOGICAL effect on erectile function.  The data is very encouraging and indicates A THERAPEUTIC SUCCESSS of this second generation technology for treating ED.”

“We also noticed this treatment is feasible and easy to administer and with no side effects reported.”  

Low Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction

-Srini Satya Vasan, Reddy Kumar Rahul, Shultz Tamar, and Denes Bela

“We found a SIGNIFICANT INCREASE IN THE ERECTION HARDNESS SCORE (EHS) AND INTERNATIONAL INDEX OF ERECTILE FUNCTION-ERECTILE FUNCTION DOMAIN (IIEF-EF DOMAIN) from visit 1 to follow up visit 5 (12 MONTHS) in the treated group compared to the placebo group.  The treatment was well tolerated and none of the men experienced treatment related discomfort or reported any adverse effects from the treatment.”

Initial Experience with Linear Focused Shockwave Treatment for Erectile Dysfunction: a 6-Month Follow-Up Pilot Study

-Y Reisman, A Hind, A Varaneckas, and I Motil

“81% HAD A SUCCESSFUL TREATMENT.  No adverse events were reported during the treatment and the follow-up duration.”

Therapeutic Advances in the Treatment of Peyronie’s Disease

-F. A. Yafi, M. R. Pinsky, P. Sangkum and W. J.G. Hellstrom

“For the management of acute phase of Peyronie’s Disease, there are currently numerous available oral drugs, but the scientific evidence for them is weak.”

A First Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Evaluating Extracorporeal Shock Wave Therapy for the Treatment of Peyronie’s Disease

-A. Palmieri, C. Imbimbo, N. Longo, F. Fusco, P. Verze, F. Mangiapia, and V. Mirone

“In patients with PD, wave therapy leads to pain resolution and ameliorates both Erectile Function (EF) and Quality of Life (QoL).

Can Low-Intensity Extracorporeal Shockwave Therapy Improve Erectile Function? A 6-Month Follow-Up Pilot Study in Patients with Organic Erectile Dysfunction

-Yoram Vardi, Boaz Appel, Giris Jacob, Omar Massarwi, and Ilan Gruenwald

“The results of this pilot study emphasize the efficacy and tolerability of penile low-intensity wave treatment in ED.  Based on our results, low-intensity wave treatment appears to HAVE THE POTENTIAL TO BE A RAPID AND CURATIVE THERAPY FOR ED.”

Tadalafil Once Daily and Extracorporeal Shock Wave Therapy in the Management of Patients with Peyronie’s Disease and Erectile Dysfunction: Results From a Prospective Randomized Trial

-A. Palmieri, C. Imbibmo, M. Creta, P. Verze, F. Fusco, and V. Mirone

“The number of patients with persistent ED was significantly lower among those receiving the combination therapy.  Quality of Life (QoL) score was significantly higher in patients receiving the combination therapy.”

Low-Intensity Shockwave Therapy Improves Hemodynamic Parameters in Patients with Vasculogenic Erectile Dysfunction

-D. Kalyvianakis and D. Hatzichristou

“The present study confirms the beneficial effect of low-intensity wave therapy on penile hemodynamics and the beneficial effect of this treatment up to 12 months.”

Peryornie’s Disease – the Plymouth Experience of Extracorporeal Shockwave Treatment

-R. Hamm, E. McLarty, J. Ashdown, S. Natale, and A. Dickinson

“Extracorporeal wave therapy produced a significant improvement in pain and penile angle, with no serious complications.”

Low-Intensity Extracorporeal Shock Wave Therapy – A Novel Effective Treatment for Erectile Dysfunction in Severe ED Patients Who Respond Poorly to PDE5 Inhibitor Therapy

-Ilan Grenwald, Boaz Appel, and Yoram Vardi

“These preliminary results of the effect of low-intensity wave therapy in a group of men with severe ED who were nonresponders to PDE5i suggest that low-intensity wave therapy HAS A PHYSIOLOGICAL EFFECT ON THE ERECTILE MECHANISM.”

“The magnitude of response is impressive and the objective hemodynamic data show significant changes posttreatment.”

Intensity Extracorporeal Shock Wave Therapy Have a Physiological Effect on Erectile Function?  Short-Term Results of a Randomized, Double-Blind, Sham Controlled Study

-Yoram Vardi, Boaz Appel, Amichai Kilchevsky and Ilan Gruenwald

“Low-intensity wave therapy has been shown to have a beneficial effect on erectile function in men with ED and cardiovascular risk factors.  We also found that this treatment is feasible and tolerable, AND IS UNIQUE IN THAT IT HAS REHABILITATIVE CHARACTERISTICS.”

Effects of Low-Intensity Extracorporeal Shockwave Therapy on Erectile Dysfunction: A Systematic Review and Meta-Analysis

-Raul I. Clavijo, Taylor P. Kohn, Jaden R. Kohn, and Ranjith Ramasamy

“In this meta-analysis of seven randomized controlled trials, treatment of ED with low-intensity wave therapy resulted in a significant increase in the International Index of Erectile Function (IIEF-EF).”

Shockwave Treatment of Erectile Dysfunction

-Ilan Gruenwald, Boaz Appel, Noam D. Kitrey and Yoram Vardi

“The results of our studies, which also included a double-blind randomized control trial, confirm that low-intensity wave therapy generates a significant clinical improvement of erectile function and a significant improvement in penile hemodynamics without any adverse effects.  Low-intensity wave therapy may create a new standard of care for men with vasculogenic ED.”

Evaluation of Clinical Efficacy, Safety and Patient Satisfaction Rate After Low-Intensity Extracorporeal Shockwave Therapy for the Treatment of Male Erectile Dysfunction: an Australian First Open-Label Single-Arm Prospective Clinical Trial

-Eric Chung and Ross Cartmill

“Low-intensity therapy appears to improve erectile function, is safe and potential plays an IMPORTANT ROLE IN PENILE REHABILITATION in men who failed medical therapy.”

Penile Low-Intensity Shock Wave Therapy: A Promising Novel Modality for Erectile Dysfunction

-Yasmin Abu-Ghanem, Noam K. Kitrey, Ilan Gruenwald, Boaz Appel, and Yoram Vardi

“Low-intensity wave therapy is a promising novel therapeutic modality for restoring erectile function in men with vasculogenic ED.  It is a safe and nonpainful treatment WITH LONG-LASTING EFFECT ON ERECTILE FUNCTION.”

Can Low-Intensity Extracorporeal Shockwave Therapy Improve Erectile Dysfunction?  A Prospective, Randomized, Double-Blind, Placebo-Controlled Study

-Anne B. Olsen, Marie Persiani, Sisdel Bole, Milad Hanna, and Lars Lund

“This placebo-controlled study over 5 weeks (5 treatments) shows that 57% of the men who suffered from erectile dysfunction had an effect from low-intensity wave therapy.”

Is There a Role for Extracorporeal Shock Wave Therapy for Erectile Dysfunction Unresponsive to Phosphodiesterase Type 5 Inhibitors?

-Zi jun Zou, Zhi-hong Liu, Liang-you Tang, Yi-ping Lu

“It appears that wave therapy is an effective noninvasive means of improving response to PDE5is and may lead TO THE RECOVERY OF SPONTANEOUS ERECTILE FUNCTION in some patients.”

Low-Intensity Extracorporeal Shock Wave Therapy in Vascular Disease and Erectile Dysfunction: Theory and Outcomes

-Ilan Gruenwald, Noam D. Kitrey, Boaz Appel, and Yoram Vardi

“Low-intensity wave therapy has the potential to improve AND PERMANENTLY RESTORE ERECTILE FUNCTION BY REINSTATING PENILE BLOOD FLOW.”